Essential role of the interleukin 2-interleukin 2 receptor pathway in thymocyte maturation in vivo.
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چکیده
منابع مشابه
Essential role of the interleukin 2-interleukin 2 receptor pathway in thymocyte maturation in vivo
The role of the IL-2-IL-2-R pathway in thymocyte differentiation in vivo is unknown. We have examined fetal thymocyte development in vivo, under conditions where all IL-2-R were saturated from day 13 of gestation with anti-IL-2-R mAbs that were previously shown to render mature T cells unable to respond to IL-2. This produced a dramatic change in the composition of developing T cells: thymocyte...
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ژورنال
عنوان ژورنال: Journal of Experimental Medicine
سال: 1988
ISSN: 0022-1007,1540-9538
DOI: 10.1084/jem.168.5.1741